ORCHESTRA BIOMED HOLDINGS IN OBIO
$4.19
-2.6% 52w: $2.35 – $5.35
Latest 13F among current holders filed 21 days ago (Aug 12, 2026)
Price — last 12 months
research preview data2.353.855.35
Aug 18, 2025 Jul 2, 2026
Institutional holders
65
+2 QoQ
13F value
$98.2M
+9.0% QoQ
Smart-money holders
8
signal tier ≥ 2
New smart buyers
2
Q1 2026
Options barometer
6.2×
$68K calls / $11K puts
Institutional value by quarter
Number of holders
Who owns OBIO?
Q1 2026 filings| Fund | Type | Shares | Value | % of fund | Change |
|---|---|---|---|---|---|
| RTW INVESTMENTS, LP ★2 | Fundamental diversified | 8.3M | $35.3M | — | Held |
| PERCEPTIVE ADVISORS LLC ★2 | Fundamental diversified | 5.0M | $21.4M | — | -1.7% |
| VANGUARD CAPITAL MANAGEMENT LLC | Diversified mechanical | 2.2M | $9.4M | — | — |
| Alyeska Investment Group, L.P. | Quant stat arb | 1.0M | $4.3M | — | Held |
| Propel Bio Management, LLC ★2 | Fundamental concentrated | 896.7K | $3.8M | — | New |
| MILLENNIUM MANAGEMENT LLC | Multistrat pod | 702.5K | $3.0M | 0.0% | +188.6% |
| BlackRock, Inc. | Index provider | 635.7K | $2.7M | 0.0% | +0.8% |
| GEODE CAPITAL MANAGEMENT, LLC | Index provider | 485.5K | $2.1M | — | +2.6% |
| Affinity Asset Advisors, LLC ★2 | Fundamental diversified | 402.6K | $1.7M | — | -29.7% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | Index provider | 265.5K | $1.1M | — | +0.6% |
| Knott David M Jr ★2 | Fundamental diversified | 253.7K | $1.1M | — | +1.5% |
| VANGUARD FIDUCIARY TRUST CO | Diversified mechanical | 235.2K | $1000K | — | — |
| Simplify Asset Management Inc. | Wealth advisor | 219.4K | $932K | — | New |
| MARSHALL WACE, LLP | Quant stat arb | 188.5K | $801K | — | +9.8% |
| 683 Capital Management, LLC ★2 | Fundamental diversified | 185.0K | $786K | — | -9.3% |
| STATE STREET CORP | Index provider | 169.4K | $720K | 0.0% | +6.5% |
| GOLDMAN SACHS GROUP INC | Bank broker | 155.2K | $660K | 0.0% | +15.8% |
| DAFNA Capital Management LLC ★2 | Fundamental diversified | 126.8K | $539K | — | Held |
| NORTHERN TRUST CORP | Index provider | 118.3K | $503K | 0.0% | +6.7% |
| Qube Research & Technologies Ltd | Quant stat arb | 109.0K | $463K | — | +2.1% |
| IFP Advisors, Inc | Wealth advisor | 98.9K | $420K | 0.0% | +14.1% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Market maker | 97.5K | $414K | 0.0% | -37.1% |
| Point72 Asset Management, L.P. | Multistrat pod | 87.9K | $374K | 0.0% | -45.7% |
| CITADEL ADVISORS LLC | Multistrat pod | 79.2K | $337K | 0.0% | +162.4% |
| Hudson Bay Capital Management LP | Multistrat pod | 71.1K | $302K | 0.0% | +43.9% |
| RENAISSANCE TECHNOLOGIES LLC | Quant stat arb | 70.9K | $301K | — | -53.1% |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | Diversified mechanical | 70.6K | $300K | — | +182.4% |
| TWO SIGMA INVESTMENTS, LP | Quant stat arb | 60.1K | $255K | 0.0% | -30.6% |
| BARCLAYS PLC | Bank broker | 59.3K | $252K | 0.0% | -37.2% |
| JANE STREET GROUP, LLC | Market maker | 55.7K | $237K | 0.0% | -68.0% |
| Daytona Street Capital LLC | Other | 52.6K | $235K | 0.2% | +144.7% |
| BANK OF AMERICA CORP /DE/ | Bank broker | 52.8K | $224K | 0.0% | +200.7% |
| Holos Integrated Wealth LLC | Wealth advisor | 51.6K | $220K | 0.1% | Held |
| UBS Group AG | Bank broker | 50.3K | $214K | 0.0% | +341.7% |
| NewEdge Advisors, LLC | Diversified mechanical | 44.1K | $187K | 0.0% | Held |
| Brevan Howard Capital Management LP | Diversified mechanical | 36.8K | $156K | — | New |
| MORGAN STANLEY | Bank broker | 35.6K | $151K | 0.0% | -56.5% |
| Meramec Financial Planners, LLC | Wealth advisor | 30.0K | $131K | 0.1% | Held |
| Catalyst Funds Management Pty Ltd | Quant stat arb | 27.6K | $117K | — | New |
| CITIGROUP INC | Bank broker | 25.5K | $108K | 0.0% | +31.2% |
| Cannon Global Investment Management, LLC ★2 | Fundamental diversified | 22.6K | $96K | — | New |
| RICE HALL JAMES & ASSOCIATES, LLC | Other | 19.0K | $81K | — | New |
| Diametric Capital, LP | Quant stat arb | 18.9K | $80K | — | New |
| HighTower Advisors, LLC | Diversified mechanical | 18.3K | $78K | 0.0% | Held |
| FMR LLC | Long only active | 18.1K | $77K | 0.0% | New |
| OMERS ADMINISTRATION Corp | Other | 16.2K | $69K | 0.0% | -75.9% |
| ALGERT GLOBAL LLC | Diversified mechanical | 14.7K | $62K | — | New |
| Vanguard Global Advisers, LLC | Diversified mechanical | 13.9K | $59K | — | — |
| ABLE Financial Group, LLC | Wealth advisor | 13.4K | $57K | 0.0% | Held |
| Frec Markets, Inc. | Quant stat arb | 13.0K | $55K | — | New |
Exits are not a bearish signal: our backtest shows stocks specialists exit keep outperforming for 3+ quarters — selling usually means profit-taking, not a forecast.
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