UPSTREAM BIO INC UPB
$7.51
+3.2% 52w: $5.92 – $32.60
Latest 13F among current holders filed 32 days ago (Jun 3, 2026)
Price — last 12 months
research preview data5.9219.2632.60
Jun 20, 2025 Jul 2, 2026
Institutional holders
141
+7 QoQ
13F value
$404.5M
-70.9% QoQ
Smart-money holders
12
signal tier ≥ 2
New smart buyers
3
Q1 2026
Options barometer
1.1×
$972K calls / $872K puts
Institutional value by quarter
Number of holders
Who owns UPB?
Q1 2026 filings| Fund | Type | Shares | Value | % of fund | Change |
|---|---|---|---|---|---|
| FMR LLC | Long only active | 8.1M | $72.9M | 0.0% | +7.8% |
| ORBIMED ADVISORS LLC ★2 | Fundamental diversified | 5.7M | $51.2M | 1.2% | Held |
| BlackRock, Inc. | Index provider | 3.4M | $30.3M | 0.0% | +0.8% |
| Decheng Capital LLC ★3 | Fundamental concentrated | 2.7M | $24.5M | 3.7% | -13.3% |
| ENAVATE SCIENCES GP, LLC ★2 | Fundamental diversified | 2.5M | $22.1M | 6.3% | Held |
| VANGUARD CAPITAL MANAGEMENT LLC | Diversified mechanical | 1.9M | $16.9M | 0.0% | — |
| Y-Intercept (Hong Kong) Ltd | Diversified mechanical | 1.0M | $9.0M | 0.2% | +2049.2% |
| FEDERATED HERMES, INC. | Diversified mechanical | 979.8K | $8.8M | 0.0% | +203169.3% |
| GEODE CAPITAL MANAGEMENT, LLC | Index provider | 950.6K | $8.6M | 0.0% | +11.6% |
| MILLENNIUM MANAGEMENT LLC | Multistrat pod | 937.3K | $8.4M | 0.0% | +81.2% |
| SEB Asset Management AB | Other | 878.5K | $7.9M | 0.0% | — |
| Bain Capital Life Sciences Investors, LLC ★3 | Fundamental concentrated | 867.2K | $7.8M | 0.7% | -34.8% |
| Woodline Partners LP | Other | 831.5K | $7.5M | 0.0% | +9.4% |
| D. E. Shaw & Co., Inc. | Quant stat arb | 820.5K | $7.4M | 0.0% | +2928.6% |
| Parkman Healthcare Partners LLC | Other | 786.8K | $7.1M | 0.7% | -5.7% |
| SAMSARA BIOCAPITAL, LLC ★3 | Fundamental concentrated | 736.0K | $6.6M | 0.6% | Held |
| Pictet Asset Management Holding SA | Diversified mechanical | 733.4K | $6.6M | 0.0% | -5.1% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | Diversified mechanical | 727.7K | $6.5M | 0.0% | — |
| STATE STREET CORP | Index provider | 705.4K | $6.3M | 0.0% | -46.5% |
| HSBC HOLDINGS PLC | Bank broker | 640.3K | $5.8M | 0.0% | New |
| Qube Research & Technologies Ltd | Quant stat arb | 619.3K | $5.6M | 0.0% | New |
| MORGAN STANLEY | Bank broker | 552.6K | $5.0M | 0.0% | +352.7% |
| JPMORGAN CHASE & CO | Bank broker | 463.0K | $4.1M | 0.0% | +319.8% |
| Nantahala Capital Management, LLC ★2 | Fundamental diversified | 400.0K | $3.6M | 0.2% | -19.2% |
| Altshuler Shaham Ltd | Other | 380.1K | $3.4M | 0.1% | -71.7% |
| SPHERA FUNDS MANAGEMENT LTD. | Other | 358.0K | $3.2M | 0.6% | New |
| Propel Bio Management, LLC ★2 | Fundamental concentrated | 341.8K | $3.1M | 2.0% | New |
| WELLINGTON MANAGEMENT GROUP LLP | Long only active | 342.4K | $3.1M | 0.0% | -61.7% |
| Jump Financial, LLC | Market maker | 319.4K | $2.9M | 0.0% | New |
| GOLDMAN SACHS GROUP INC | Bank broker | 316.6K | $2.8M | 0.0% | -5.1% |
| Alyeska Investment Group, L.P. | Quant stat arb | 298.3K | $2.7M | 0.0% | Held |
| NORTHERN TRUST CORP | Index provider | 261.0K | $2.3M | 0.0% | +10.2% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | Index provider | 257.7K | $2.3M | 0.0% | -9.5% |
| Prosight Management, LP ★2 | Fundamental concentrated | 241.1K | $2.2M | 0.4% | New |
| UBS Group AG | Bank broker | 231.3K | $2.1M | 0.0% | -87.2% |
| VANGUARD FIDUCIARY TRUST CO | Diversified mechanical | 224.2K | $2.0M | 0.0% | — |
| XTX Topco Ltd | Market maker | 209.3K | $1.9M | 0.0% | +1286.8% |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | Quant stat arb | 185.1K | $1.7M | 0.0% | New |
| TCG Crossover Management, LLC ★3 | Fundamental concentrated | 181.1K | $1.6M | 0.0% | -75.7% |
| DEUTSCHE BANK AG\ | Bank broker | 180.9K | $1.6M | 0.0% | +41.5% |
| Point72 Asset Management, L.P. | Multistrat pod | 178.2K | $1.6M | 0.0% | New |
| Trexquant Investment LP | Diversified mechanical | 176.7K | $1.6M | 0.0% | +469.0% |
| Schonfeld Strategic Advisors LLC | Multistrat pod | 161.3K | $1.5M | 0.0% | +39.3% |
| Boxer Capital Management, LLC ★2 | Fundamental concentrated | 150.0K | $1.4M | 0.2% | Held |
| BNP PARIBAS FINANCIAL MARKETS | Bank broker | 126.0K | $1.1M | 0.0% | +2432.2% |
| ALLIANCEBERNSTEIN L.P. | Long only active | 31.0K | $842K | 0.0% | Held |
| ExodusPoint Capital Management, LP | Multistrat pod | 91.4K | $823K | 0.0% | +21.3% |
| AMERICAN CENTURY COMPANIES INC | Diversified mechanical | 87.6K | $789K | 0.0% | -0.2% |
| Bank of New York Mellon Corp | Diversified mechanical | 81.4K | $732K | 0.0% | -4.1% |
| DIMENSIONAL FUND ADVISORS LP | Quant stat arb | 80.0K | $719K | 0.0% | New |
Exits are not a bearish signal: our backtest shows stocks specialists exit keep outperforming for 3+ quarters — selling usually means profit-taking, not a forecast.
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