Avidity Partners Management LP

Fundamental diversified ★Signal healthcare specialist (98%) CIK 1791827
League rank
#133
in Fundamental diversified · #591 overall
Long book
$935.7M
Q1 2026
Positions
52
Top-10 weight
81%
concentration
Last quarter
+20.2%
SPY +14.8%
Turnover
64%
of book per quarter

Strategy in plain words

auto-generated from filings

Avidity Partners Management LP is a diversified fundamental manager, specialised in healthcare (98% of the long book), running a $935.7M US long book across 52 positions.

The portfolio is extremely concentrated — the top 10 positions are almost the whole book. Turnover is high — positions rotate quickly, so individual names matter less than the process. Current anchor positions: DIANTHUS THERAPEUTICS INC, ORUKA THERAPEUTICS INC, CG ONCOLOGY INC, JADE BIOSCIENCES INC, PERSPECTIVE THERAPEUTICS INC.

Over the last 9 quarters its long book ran on average 3.5pp per quarter ahead of the S&P 500, beating the index in 5 of 9 quarters. We rate its filings as signal-bearing: position changes reflect genuine views.

Implied long-book return vs S&P 500

methodology: positions priced quarterly, no shorts/options
Fund long book S&P 500
Q1 2024
-7.1%
Q2 2024
+9.1%
Q3 2024
-12.5%
Q4 2024
-13.3%
Q1 2025
+1.0%
Q2 2025
+22.3%
Q3 2025
+11.9%
Q4 2025
+40.5%
Q1 2026
+20.2%

Sector allocation

Healthcare
98%
Financials
1%
Other
1%
Technology
1%
Materials
0%

Long book by quarter

$2.81B
Q1 2024
$2.35B
Q2 2024
$1.96B
Q3 2024
$1.00B
Q4 2024
$484.9M
Q1 2025
$498.8M
Q2 2025
$439.4M
Q3 2025
$346.7M
Q4 2025
$935.7M
Q1 2026

What does Avidity Partners own?

Q1 2026 13F
CompanySectorSharesValue% of bookChange
DNTH DIANTHUS THERAPEUTICS INCHealthcare4.2M$361.3M38.6%+100.0%
ORKA ORUKA THERAPEUTICS INCHealthcare1.5M$89.3M9.5%+130.3%
CGON CG ONCOLOGY INCHealthcare1.3M$87.2M9.3%-12.5%
JBIO JADE BIOSCIENCES INCHealthcare2.8M$53.9M5.8%+100.0%
CATX PERSPECTIVE THERAPEUTICS INCHealthcare12.1M$48.8M5.2%+276.9%
ELVN ENLIVEN THERAPEUTICS INCHealthcare800.0K$32.2M3.4%+470.2%
CNTX CONTEXT THERAPEUTICS INCHealthcare10.0M$24.9M2.7%+81.6%
RGEN REPLIGEN CORPHealthcare155.6K$18.4M2.0%+209.3%
PVLA PALVELLA THERAPEUTICS INCHealthcare140.0K$17.7M1.9%+625.4%
AKTS AKTIS ONCOLOGY INCHealthcare937.1K$17.2M1.8%New
MDT MEDTRONIC PLCHealthcare200.0K$16.8M1.8%+85.9%
VIR VIR BIOTECHNOLOGY INCHealthcare1.6M$14.8M1.6%New
IMUX IMMUNIC INCHealthcare7.4M$13.9M1.5%+56.8%
DXCM DEXCOM INCHealthcare190.0K$11.6M1.2%New
EHC ENCOMPASS HEALTH CORPHealthcare84.0K$8.3M0.9%+165.8%
BSX BOSTON SCIENTIFIC CORPHealthcare120.0K$7.2M0.8%+4.8%
TENX TENAX THERAPEUTICS INCHealthcare481.9K$6.9M0.7%New
KPTI KARYOPHARM THERAPEUTICS INCHealthcare927.5K$6.4M0.7%+589.2%
HUM HUMANA INCFinancials25.0K$5.9M0.6%New
PHAT PHATHOM PHARMACEUTICALS INCHealthcare498.8K$5.6M0.6%+142.0%
GILD GILEAD SCIENCES INCHealthcare40.0K$5.4M0.6%New
MSLE SATELLOS BIOSCIENCE INCHealthcare775.5K$5.3M0.6%New
TEM TEMPUS AI INC-CL ATechnology90.0K$4.7M0.5%New
SCYX SCYNEXIS INCHealthcare4.2M$3.8M0.4%+100.0%
ICLR ICON PLCHealthcare32.0K$3.7M0.4%-3.3%
NTRA NATERA INCHealthcare18.0K$3.7M0.4%+52.5%
CRVS CORVUS PHARMACEUTICALS INCHealthcare230.0K$3.4M0.4%New
HIMS HIMS & HERS HEALTH INCHealthcare125.0K$2.9M0.3%New
CORT CORCEPT THERAPEUTICS INCHealthcare60.0K$2.6M0.3%+172.7%
CNC CENTENE CORPFinancials70.0K$2.3M0.2%-41.4%
NTLA INTELLIA THERAPEUTICS INCMaterials150.0K$2.0M0.2%New
PTON PELOTON INTERACTIVE INC-AOther400.0K$1.9M0.2%New
ODD ODDITY TECH LTD-CL AOther140.0K$1.9M0.2%New
AVR ANTERIS TECHNOLOGIES GLOBALHealthcare300.0K$1.8M0.2%New
MLTX MOONLAKE IMMUNOTHERAPEUTICSHealthcare100.0K$1.8M0.2%New
KVUE KENVUE INCOther100.0K$1.7M0.2%-57.0%
PODD INSULET CORPHealthcare10.0K$1.7M0.2%New
CRL CHARLES RIVER LABORATORIESHealthcare10.0K$1.7M0.2%New
RVMD REVOLUTION MEDICINES INCHealthcare15.0K$1.5M0.2%New
ABUS ARBUTUS BIOPHARMA CORPHealthcare250.0K$1.1M0.1%New
UNH UNITEDHEALTH GROUP INCFinancials3.8K$1.0M0.1%New
ABT ABBOTT LABORATORIESHealthcare10.0K$908K0.1%New
BBOT BRIDGEBIO ONCOLOGY THERAPEUTHealthcare87.7K$761K0.1%New
BBIO BRIDGEBIO PHARMA INCHealthcare10.0K$711K0.1%New
ACAD ACADIA PHARMACEUTICALS INCHealthcare25.9K$580K0.1%-75.7%
SVRA SAVARA INCHealthcare50.0K$262K0.0%New
TRVI TREVI THERAPEUTICS INCHealthcare13.3K$171K0.0%New

13F filing history

PeriodFormFiledEntriesReported valueFlagsSource
Q1 202613F-HR/ANEW HOLDINGSMay 28, 202645$493.8M canonicalSEC ↗
Q1 202613F-HRMay 13, 202646$441.9M canonicalSEC ↗
Q4 202513F-HRFeb 13, 202639$346.7M canonicalSEC ↗
Q3 202513F-HRNov 14, 202543$439.4M canonicalSEC ↗
Q2 202513F-HRAug 14, 202556$502.0M canonicalSEC ↗
Q1 202513F-HRMay 15, 202567$524.7M canonicalSEC ↗
Q4 202413F-HRFeb 14, 202563$1.02B canonicalSEC ↗
Q3 202413F-HRNov 14, 202481$1.96B canonicalSEC ↗
Q2 202413F-HRAug 14, 202485$2.35B canonicalSEC ↗
Q1 202413F-HRMay 15, 202490$3.10B canonicalSEC ↗