DEERFIELD MANAGEMENT COMPANY, L.P.

Quant stat arb Low signal healthcare specialist (96%) CIK 1009258
League rank
#30
in Quant stat arb · #846 overall
Long book
$7.18B
Q1 2026
Positions
73
Top-10 weight
54%
concentration
Last quarter
+17.9%
SPY +14.8%
Turnover
58%
of book per quarter

Strategy in plain words

auto-generated from filings

DEERFIELD MANAGEMENT COMPANY, L.P. is a quantitative fund whose holdings reflect models, not opinions, specialised in healthcare (96% of the long book), running a $7.18B US long book across 73 positions.

The portfolio is concentrated: the top 10 names carry 54% of the portfolio. Turnover is high — positions rotate quickly, so individual names matter less than the process. Current anchor positions: NUVALENT INC-A, COGENT BIOSCIENCES INC, PRAXIS PRECISION MEDICINES I, VIATRIS INC, UNITED THERAPEUTICS CORP.

Over the last 9 quarters its long book ran on average 1.1pp per quarter ahead of the S&P 500, beating the index in 5 of 9 quarters. Signal value of individual moves is limited — treat changes as weak evidence.

Implied long-book return vs S&P 500

methodology: positions priced quarterly, no shorts/options
Fund long book S&P 500
Q1 2024
-7.9%
Q2 2024
+21.0%
Q3 2024
-16.2%
Q4 2024
-10.7%
Q1 2025
+7.4%
Q2 2025
+12.2%
Q3 2025
+26.5%
Q4 2025
+0.3%
Q1 2026
+17.9%

Sector allocation

Healthcare
93%
Financials
3%
Other
2%
Materials
1%
Technology
1%

Long book by quarter

$5.21B
Q1 2024
$5.18B
Q2 2024
$6.04B
Q3 2024
$4.66B
Q4 2024
$4.42B
Q1 2025
$4.93B
Q2 2025
$6.03B
Q3 2025
$6.84B
Q4 2025
$7.18B
Q1 2026

What does DEERFIELD MANAGEMENT own?

Q1 2026 13F
CompanySectorSharesValue% of bookChange
NUVL NUVALENT INC-AHealthcare17.2M$1.77B24.6%Held
COGT COGENT BIOSCIENCES INCHealthcare9.0M$348.1M4.9%Held
PRAX PRAXIS PRECISION MEDICINES IHealthcare963.4K$310.4M4.3%+6.6%
VTRS VIATRIS INCHealthcare20.2M$273.0M3.8%Held
UTHR UNITED THERAPEUTICS CORPHealthcare457.0K$271.0M3.8%+7.3%
RVMD REVOLUTION MEDICINES INCHealthcare2.3M$223.4M3.1%-20.6%
CELC CELCUITY INCHealthcare1.7M$195.6M2.7%Held
CNC CENTENE CORPFinancials5.9M$193.7M2.7%-8.2%
LRMR LARIMAR THERAPEUTICS INCHealthcare35.6M$160.2M2.2%+16.3%
BKD BROOKDALE SENIOR LIVING INCHealthcare11.6M$159.2M2.2%Held
VERA VERA THERAPEUTICS INCHealthcare3.7M$149.7M2.1%-8.3%
IONS IONIS PHARMACEUTICALS INCHealthcare2.0M$148.7M2.1%Held
BCRX BIOCRYST PHARMACEUTICALS INCHealthcare15.0M$143.2M2.0%+4.9%
INSP INSPIRE MEDICAL SYSTEMS INCHealthcare2.7M$139.4M1.9%+79.5%
AHCO ADAPTHEALTH CORPHealthcare11.5M$136.6M1.9%Held
NAMS NEWAMSTERDAM PHARMA CO NVHealthcare4.3M$136.5M1.9%+2.4%
ACHC ACADIA HEALTHCARE CO INCHealthcare4.5M$105.7M1.5%Held
ARWR ARROWHEAD PHARMACEUTICALS INHealthcare1.6M$98.6M1.4%-14.2%
CPRX CATALYST PHARMACEUTICALS INCHealthcare3.9M$97.6M1.4%-19.7%
INDV INDIVIOR PHARMACEUTICALS INCHealthcare3.1M$94.4M1.3%New
XENE XENON PHARMACEUTICALS INCHealthcare1.6M$94.0M1.3%+198.1%
PHVS PHARVARIS NVHealthcare3.1M$88.3M1.2%Held
SNDX SYNDAX PHARMACEUTICALS INCHealthcare3.8M$88.3M1.2%New
TNGX TANGO THERAPEUTICS INCHealthcare4.1M$86.8M1.2%+42.7%
DNTH DIANTHUS THERAPEUTICS INCHealthcare1.0M$85.6M1.2%New
PFE PFIZER INCHealthcare3.0M$85.4M1.2%New
NBIX NEUROCRINE BIOSCIENCES INCHealthcare610.0K$80.4M1.1%-48.5%
DAWNGBX DAY ONE BIOPHARMACEUTICALS I3.7M$79.8M1.1%Held
SVRA SAVARA INCHealthcare13.6M$74.1M1.0%Held
EHABUSD ENHABIT INC4.7M$66.9M0.9%Held
BIO BIO-RAD LABORATORIES-AHealthcare226.1K$63.0M0.9%Held
LNTH LANTHEUS HOLDINGS INCMaterials828.0K$62.8M0.9%Held
SPRY ARS PHARMACEUTICALS INCHealthcare7.5M$60.3M0.8%Held
STOK STOKE THERAPEUTICS INCHealthcare1.8M$59.4M0.8%Held
NVST ENVISTA HOLDINGS CORPHealthcare2.2M$56.1M0.8%-3.1%
IDYA IDEAYA BIOSCIENCES INCHealthcare1.5M$51.0M0.7%-28.9%
BMRN BIOMARIN PHARMACEUTICAL INCHealthcare851.6K$48.1M0.7%New
KYMR KYMERA THERAPEUTICS INCHealthcare561.2K$46.7M0.7%Held
CERT CERTARA INCTechnology7.8M$44.5M0.6%Held
BBOT BRIDGEBIO ONCOLOGY THERAPEUTHealthcare4.9M$43.7M0.6%Held
IRON DISC MEDICINE INCHealthcare657.0K$42.0M0.6%+28.5%
SION SIONNA THERAPEUTICS INCHealthcare970.6K$38.9M0.5%Held
CDNA CAREDX INCHealthcare2.2M$38.0M0.5%Held
VCYT VERACYTE INCHealthcare726.0K$23.4M0.3%Held
ALNY ALNYLAM PHARMACEUTICALS INCHealthcare67.9K$22.5M0.3%Held
EMBC EMBECTA CORPHealthcare2.5M$22.4M0.3%-7.9%
TYRA TYRA BIOSCIENCES INCHealthcare549.0K$21.0M0.3%New
FHTX FOGHORN THERAPEUTICS INCHealthcare4.4M$21.0M0.3%+20.4%
DRUG BRIGHT MINDS BIOSCIENCES INCHealthcare283.0K$20.7M0.3%New
CMPX COMPASS THERAPEUTICS INCHealthcare3.6M$19.1M0.3%Held

13F filing history

PeriodFormFiledEntriesReported valueFlagsSource
Q1 202613F-HRMay 15, 202682$8.48B canonicalSEC ↗
Q4 202513F-HRFeb 17, 2026150$7.83B canonicalSEC ↗
Q3 202513F-HRNov 14, 2025152$6.55B canonicalSEC ↗
Q2 202513F-HRAug 14, 2025124$5.51B canonicalSEC ↗
Q1 202513F-HRMay 15, 2025123$5.06B canonicalSEC ↗
Q4 202413F-HRFeb 14, 2025106$5.28B canonicalSEC ↗
Q3 202413F-HRNov 14, 2024443$6.69B canonicalSEC ↗
Q2 202413F-HRAug 14, 2024433$6.01B canonicalSEC ↗
Q1 202413F-HRMay 15, 2024367$5.75B canonicalSEC ↗