Crestline Management, L.P.

Fundamental diversified ★Signal healthcare specialist (96%) CIK 1536054
League rank
#671
in Fundamental diversified · #5822 overall
Long book
$46.3M
Q1 2026
Positions
3
Top-10 weight
100%
concentration
Last quarter
+33.9%
SPY +14.8%
Turnover
0%
of book per quarter

Strategy in plain words

auto-generated from filings

Crestline Management, L.P. is a diversified fundamental manager, specialised in healthcare (96% of the long book), running a $46.3M US long book across 3 positions.

The portfolio is extremely concentrated — the top 10 positions are almost the whole book. The book barely moves quarter to quarter — a patient, low-turnover holder. Current anchor positions: DENALI THERAPEUTICS INC, SANA BIOTECHNOLOGY INC, 8X8 INC.

Over the last 9 quarters its long book ran on average 3.4pp per quarter ahead of the S&P 500, beating the index in 4 of 9 quarters. We rate its filings as signal-bearing: position changes reflect genuine views.

Implied long-book return vs S&P 500

methodology: positions priced quarterly, no shorts/options
Fund long book S&P 500
Q1 2024
+0.8%
Q2 2024
+6.5%
Q3 2024
-1.4%
Q4 2024
-6.2%
Q1 2025
+7.2%
Q2 2025
+6.7%
Q3 2025
+13.1%
Q4 2025
+10.9%
Q1 2026
+33.9%

Sector allocation

Healthcare
96%
Technology
4%

Long book by quarter

$1.06B
Q1 2024
$1.27B
Q2 2024
$1.76B
Q3 2024
$2.87B
Q4 2024
$63.2M
Q1 2025
$62.6M
Q2 2025
$58.1M
Q3 2025
$53.3M
Q4 2025
$46.3M
Q1 2026

What does Crestline Management, own?

Q1 2026 13F
CompanySectorSharesValue% of bookChange
DNLI DENALI THERAPEUTICS INCHealthcare2.2M$42.4M91.7%-21.3%
SANA SANA BIOTECHNOLOGY INCHealthcare755.7K$2.2M4.7%-38.1%
EGHT 8X8 INCTechnology990.9K$1.6M3.6%0.0%

13F filing history

PeriodFormFiledEntriesReported valueFlagsSource
Q1 202613F-HRMay 15, 20263$46.3M SEC ↗
Q1 202613F-HR/ARESTATEMENTMay 15, 20263$46.3M canonicalSEC ↗
Q4 202513F-HRFeb 17, 20263$53.3M canonicalSEC ↗
Q3 202513F-HRNov 14, 20253$58.1M canonicalSEC ↗
Q2 202513F-HRAug 14, 20253$62.6M canonicalSEC ↗
Q1 202513F-HRMay 15, 20253$63.2M canonicalSEC ↗
Q4 202413F-HRFeb 14, 2025705$3.01B canonicalSEC ↗
Q3 202413F-HRNov 13, 2024514$1.92B canonicalSEC ↗
Q2 202413F-HRAug 14, 2024159$1.28B canonicalSEC ↗
Q1 202413F-HRMay 14, 2024157$1.13B canonicalSEC ↗