Sofinnova Investments, Inc.

Fundamental diversified ★Signal healthcare specialist (100%) CIK 1631134
League rank
#254
in Fundamental diversified · #1106 overall
Long book
$2.00B
Q1 2026
Positions
61
Top-10 weight
55%
concentration
Last quarter
+16.6%
SPY +14.8%
Turnover
43%
of book per quarter

Strategy in plain words

auto-generated from filings

Sofinnova Investments, Inc. is a diversified fundamental manager, specialised in healthcare (100% of the long book), running a $2.00B US long book across 61 positions.

The portfolio is concentrated: the top 10 names carry 55% of the portfolio. The portfolio is actively managed, with meaningful quarterly turnover. Current anchor positions: NATERA INC, BRISTOL-MYERS SQUIBB CO, JAZZ PHARMACEUTICALS PLC, VERA THERAPEUTICS INC, UNITED THERAPEUTICS CORP.

Over the last 9 quarters its long book ran on average 3.1pp per quarter ahead of the S&P 500, beating the index in 4 of 9 quarters. We rate its filings as signal-bearing: position changes reflect genuine views.

Implied long-book return vs S&P 500

methodology: positions priced quarterly, no shorts/options
Fund long book S&P 500
Q1 2024
+2.6%
Q2 2024
+3.6%
Q3 2024
-7.1%
Q4 2024
-10.8%
Q1 2025
+5.9%
Q2 2025
+22.3%
Q3 2025
+35.8%
Q4 2025
-0.8%
Q1 2026
+16.6%

Sector allocation

Healthcare
100%
Materials
0%
Other
0%

Long book by quarter

$1.69B
Q1 2024
$1.59B
Q2 2024
$1.21B
Q3 2024
$1.36B
Q4 2024
$1.33B
Q1 2025
$1.47B
Q2 2025
$1.63B
Q3 2025
$2.32B
Q4 2025
$2.00B
Q1 2026

What does Sofinnova Investments, own?

Q1 2026 13F
CompanySectorSharesValue% of bookChange
NTRA NATERA INCHealthcare1.6M$310.0M15.5%Held
BMY BRISTOL-MYERS SQUIBB COHealthcare2.0M$120.6M6.0%+31.4%
JAZZ JAZZ PHARMACEUTICALS PLCHealthcare598.3K$113.1M5.7%-37.7%
VERA VERA THERAPEUTICS INCHealthcare2.8M$112.4M5.6%Held
UTHR UNITED THERAPEUTICS CORPHealthcare160.1K$94.9M4.8%+1.5%
AZN ASTRAZENECA PLCHealthcare456.0K$89.9M4.5%New
COGT COGENT BIOSCIENCES INCHealthcare2.1M$81.4M4.1%+7.1%
RARE ULTRAGENYX PHARMACEUTICAL INHealthcare3.1M$65.9M3.3%+3676.6%
RAPP RAPPORT THERAPEUTICS INCHealthcare1.9M$59.6M3.0%Held
INSM INSMED INCHealthcare346.1K$56.6M2.8%+120.7%
ALC ALCON INCHealthcare730.0K$55.0M2.8%+119.5%
SUPN SUPERNUS PHARMACEUTICALS INCHealthcare954.3K$49.3M2.5%+72.5%
BMRN BIOMARIN PHARMACEUTICAL INCHealthcare782.0K$44.2M2.2%+12.2%
BIIB BIOGEN INCHealthcare229.5K$42.1M2.1%New
CELC CELCUITY INCHealthcare366.2K$41.8M2.1%+22.3%
BIOA BIOAGE LABS INCHealthcare2.3M$40.1M2.0%Held
RYTM RHYTHM PHARMACEUTICALS INCHealthcare450.1K$39.1M2.0%+65.8%
AVBP ARRIVENT BIOPHARMA INCHealthcare1.7M$39.1M2.0%Held
IDYA IDEAYA BIOSCIENCES INCHealthcare1.1M$37.7M1.9%+27.9%
IMNM IMMUNOME INCHealthcare1.7M$37.2M1.9%+5.2%
NKTR NEKTAR THERAPEUTICSHealthcare509.5K$36.7M1.8%+16.2%
AXSM AXSOME THERAPEUTICS INCHealthcare212.7K$36.0M1.8%+1634.4%
IMTX IMMATICS NVHealthcare3.6M$35.7M1.8%+5.7%
BBIO BRIDGEBIO PHARMA INCHealthcare409.2K$30.4M1.5%-43.2%
DYN DYNE THERAPEUTICS INCHealthcare1.6M$29.6M1.5%-27.5%
INBX INHIBRX BIOSCIENCES INCHealthcare406.0K$27.3M1.4%-10.7%
DXCM DEXCOM INCHealthcare393.6K$24.7M1.2%+4.1%
PHVS PHARVARIS NVHealthcare818.3K$23.1M1.2%+9.8%
PRAX PRAXIS PRECISION MEDICINES IHealthcare63.7K$20.5M1.0%-49.3%
RCUS ARCUS BIOSCIENCES INCHealthcare923.1K$19.9M1.0%-15.8%
XENE XENON PHARMACEUTICALS INCHealthcare305.2K$17.7M0.9%+409.5%
SYK STRYKER CORPHealthcare44.5K$14.6M0.7%New
ANAB ANAPTYSBIO INCHealthcare248.3K$13.8M0.7%-13.7%
ROIV ROIVANT SCIENCES LTDHealthcare478.0K$13.2M0.7%-34.9%
EWTX EDGEWISE THERAPEUTICS INCHealthcare386.5K$12.2M0.6%-11.7%
CMPX COMPASS THERAPEUTICS INCHealthcare2.1M$10.9M0.5%-38.9%
ORIC ORIC PHARMACEUTICALS INCHealthcare679.6K$8.6M0.4%New
TNGX TANGO THERAPEUTICS INCHealthcare395.1K$8.3M0.4%New
TYRA TYRA BIOSCIENCES INCHealthcare204.0K$7.8M0.4%New
AXGN AXOGEN INCHealthcare210.7K$7.0M0.3%New
DFTX DEFINIUM THERAPEUTICS INCMaterials344.2K$6.5M0.3%New
CYTK CYTOKINETICS INCHealthcare91.8K$6.0M0.3%New
IRON DISC MEDICINE INCHealthcare78.3K$5.0M0.3%-29.4%
MANE VERADERMICS INCHealthcare73.3K$4.6M0.2%New
HRMY HARMONY BIOSCIENCES HOLDINGSHealthcare152.7K$4.3M0.2%New
PCVX VAXCYTE INCHealthcare50.6K$2.9M0.1%New
MIRM MIRUM PHARMACEUTICALS INCHealthcare27.6K$2.5M0.1%+19.4%
NXTC NEXTCURE INCHealthcare222.7K$2.4M0.1%Held
SVRA SAVARA INCHealthcare364.8K$2.0M0.1%+19.7%
ESTA ESTABLISHMENT LABS HOLDINGSHealthcare33.9K$1.9M0.1%+19.6%

13F filing history

PeriodFormFiledEntriesReported valueFlagsSource
Q1 202613F-HRMay 15, 202675$2.63B canonicalSEC ↗
Q4 202513F-HRFeb 13, 202660$2.32B canonicalSEC ↗
Q3 202513F-HRNov 14, 202562$1.83B canonicalSEC ↗
Q2 202513F-HRAug 14, 202563$1.64B canonicalSEC ↗
Q1 202513F-HRMay 15, 202565$1.53B canonicalSEC ↗
Q4 202413F-HRFeb 14, 202561$1.37B canonicalSEC ↗
Q3 202413F-HRNov 13, 202462$1.26B canonicalSEC ↗
Q2 202413F-HRAug 9, 202482$1.92B canonicalSEC ↗
Q1 202413F-HR/ARESTATEMENTAug 14, 202474$1.80B canonicalSEC ↗
Q1 202413F-HRMay 15, 202474$1.80B SEC ↗