Soleus Capital Management, L.P.

Fundamental diversified ★Signal healthcare specialist (100%) CIK 1802630
League rank
#51
in Fundamental diversified · #254 overall
Long book
$2.47B
Q1 2026
Positions
93
Top-10 weight
50%
concentration
Last quarter
+27.3%
SPY +14.8%
Turnover
43%
of book per quarter

Strategy in plain words

auto-generated from filings

Soleus Capital Management, L.P. is a diversified fundamental manager, specialised in healthcare (100% of the long book), running a $2.47B US long book across 93 positions.

The portfolio is concentrated: the top 10 names carry 50% of the portfolio. The portfolio is actively managed, with meaningful quarterly turnover. Current anchor positions: KRYSTAL BIOTECH INC, CELCUITY INC, TG THERAPEUTICS INC, INSULET CORP, NOVOCURE LTD.

Over the last 9 quarters its long book ran on average 2.7pp per quarter ahead of the S&P 500, beating the index in 5 of 9 quarters. We rate its filings as signal-bearing: position changes reflect genuine views.

Implied long-book return vs S&P 500

methodology: positions priced quarterly, no shorts/options
Fund long book S&P 500
Q1 2024
-9.4%
Q2 2024
+12.2%
Q3 2024
-9.0%
Q4 2024
-10.1%
Q1 2025
-6.0%
Q2 2025
+23.9%
Q3 2025
+35.4%
Q4 2025
+0.5%
Q1 2026
+27.3%

Sector allocation

Healthcare
100%
Technology
0%
Services media
0%

Long book by quarter

$1.14B
Q1 2024
$1.13B
Q2 2024
$1.20B
Q3 2024
$1.32B
Q4 2024
$1.28B
Q1 2025
$1.45B
Q2 2025
$1.87B
Q3 2025
$2.36B
Q4 2025
$2.47B
Q1 2026

What does Soleus Capital own?

Q1 2026 13F
CompanySectorSharesValue% of bookChange
KRYS KRYSTAL BIOTECH INCHealthcare1.2M$297.9M12.1%+22.5%
CELC CELCUITY INCHealthcare1.3M$146.6M5.9%-29.0%
TGTX TG THERAPEUTICS INCHealthcare4.0M$133.9M5.4%+28.4%
PODD INSULET CORPHealthcare562.5K$118.0M4.8%+275.0%
NVCR NOVOCURE LTDHealthcare10.5M$114.4M4.6%+23.0%
UTHR UNITED THERAPEUTICS CORPHealthcare187.2K$111.0M4.5%+212.0%
PRAX PRAXIS PRECISION MEDICINES IHealthcare330.5K$106.5M4.3%-8.9%
VCEL VERICEL CORPHealthcare2.5M$82.0M3.3%+233.6%
ALKS ALKERMES PLCHealthcare2.0M$69.7M2.8%+49.0%
ANIP ANI PHARMACEUTICALS INCHealthcare820.2K$63.1M2.6%+68.7%
GMED GLOBUS MEDICAL INC - AHealthcare729.5K$62.9M2.5%-17.8%
GERN GERON CORPHealthcare41.5M$61.8M2.5%+78.2%
TWST TWIST BIOSCIENCE CORPHealthcare1.2M$58.3M2.4%-34.1%
EWTX EDGEWISE THERAPEUTICS INCHealthcare1.4M$45.7M1.8%+59.3%
BBNX BETA BIONICS INCHealthcare4.4M$43.6M1.8%+71.8%
ALNY ALNYLAM PHARMACEUTICALS INCHealthcare131.7K$43.6M1.8%+88.1%
SNDX SYNDAX PHARMACEUTICALS INCHealthcare1.7M$40.3M1.6%-23.1%
INDV INDIVIOR PHARMACEUTICALS INCHealthcare1.3M$38.8M1.6%New
NPCE NEUROPACE INCHealthcare2.9M$38.6M1.6%+8.5%
LIVN LIVANOVA PLCHealthcare582.5K$37.0M1.5%+2.6%
MIRM MIRUM PHARMACEUTICALS INCHealthcare400.3K$37.0M1.5%-30.2%
BMRN BIOMARIN PHARMACEUTICAL INCHealthcare650.6K$36.8M1.5%-50.7%
PGNY PROGYNY INCHealthcare2.1M$35.1M1.4%New
INSP INSPIRE MEDICAL SYSTEMS INCHealthcare576.3K$29.7M1.2%+92.5%
KNSA KINIKSA PHARMACEUTICALS INTEHealthcare521.4K$25.1M1.0%-11.2%
MRK MERCK & CO. INC.Healthcare203.0K$24.4M1.0%New
ORGO ORGANOGENESIS HOLDINGS INCHealthcare10.1M$23.9M1.0%+1.0%
NTRA NATERA INCHealthcare119.0K$23.8M1.0%+495.0%
AXGN AXOGEN INCHealthcare679.2K$22.5M0.9%-43.7%
PCVX VAXCYTE INCHealthcare385.5K$22.4M0.9%-36.7%
ICLR ICON PLCHealthcare192.0K$21.2M0.9%New
PHVS PHARVARIS NVHealthcare702.1K$19.8M0.8%Held
CERS CERUS CORPHealthcare10.8M$19.6M0.8%+168.8%
TRVI TREVI THERAPEUTICS INCHealthcare1.6M$19.3M0.8%+80.0%
IKT INHIBIKASE THERAPEUTICS INCHealthcare10.9M$18.3M0.7%Held
CNTX CONTEXT THERAPEUTICS INCHealthcare7.0M$18.2M0.7%New
VIR VIR BIOTECHNOLOGY INCHealthcare2.0M$17.9M0.7%New
XENE XENON PHARMACEUTICALS INCHealthcare292.0K$17.0M0.7%New
TVTX TRAVERE THERAPEUTICS INCHealthcare546.0K$16.2M0.7%New
TNDM TANDEM DIABETES CARE INCHealthcare783.0K$15.0M0.6%New
NRIX NURIX THERAPEUTICS INCHealthcare938.2K$14.5M0.6%-23.1%
URGN UROGEN PHARMA LTDHealthcare727.0K$13.1M0.5%+384.7%
SION SIONNA THERAPEUTICS INCHealthcare293.5K$11.8M0.5%+9.3%
CORT CORCEPT THERAPEUTICS INCHealthcare285.5K$11.5M0.5%New
JBIO JADE BIOSCIENCES INCHealthcare796.7K$11.2M0.5%Held
VCYT VERACYTE INCHealthcare319.9K$10.3M0.4%+3099.1%
IVVD INVIVYD INCHealthcare7.7M$10.0M0.4%Held
CCCC C4 THERAPEUTICS INCHealthcare3.8M$10.0M0.4%Held
KIDS ORTHOPEDIATRICS CORPHealthcare615.4K$9.8M0.4%+17.1%
RCUS ARCUS BIOSCIENCES INCHealthcare452.0K$9.8M0.4%-36.5%

13F filing history

PeriodFormFiledEntriesReported valueFlagsSource
Q1 202613F-HRMay 14, 202693$2.47B canonicalSEC ↗
Q4 202513F-HRFeb 12, 202695$2.71B canonicalSEC ↗
Q3 202513F-HRNov 14, 202588$1.99B canonicalSEC ↗
Q2 202513F-HRAug 15, 202595$1.51B canonicalSEC ↗
Q1 202513F-HRMay 15, 202575$1.39B canonicalSEC ↗
Q4 202413F-HRFeb 14, 202581$1.59B canonicalSEC ↗
Q3 202413F-HRNov 14, 202487$1.29B canonicalSEC ↗
Q2 202413F-HRAug 14, 202492$1.13B canonicalSEC ↗
Q1 202413F-HRMay 15, 202491$1.35B canonicalSEC ↗