SPYRE THERAPEUTICS INC SYRE
$86.63
-2.5% 52w: $14.68 – $100.32
Latest 13F among current holders filed 30 days ago (Jun 4, 2026)
Price — last 12 months
research preview data14.6857.50100.32
Jun 20, 2025 Jul 2, 2026
Institutional holders
198
+44 QoQ
13F value
$4.17B
+57.3% QoQ
Smart-money holders
26
signal tier ≥ 2
New smart buyers
6
Q1 2026
Options barometer
10.5×
$16.4M calls / $1.6M puts
Institutional value by quarter
Number of holders
Who owns SYRE?
Q1 2026 filings| Fund | Type | Shares | Value | % of fund | Change |
|---|---|---|---|---|---|
| FMR LLC | Long only active | 11.8M | $594.2M | 0.0% | +1.2% |
| BlackRock, Inc. | Index provider | 5.5M | $278.5M | 0.0% | 0.0% |
| RTW INVESTMENTS, LP ★2 | Fundamental diversified | 4.2M | $210.4M | 2.1% | Held |
| Fairmount Funds Management LLC ★3 | Fundamental concentrated | 4.0M | $202.7M | 14.6% | Held |
| PERCEPTIVE ADVISORS LLC ★2 | Fundamental diversified | 3.8M | $190.8M | 3.8% | +23.3% |
| Venrock Adviser, LLC ★3 | Fundamental concentrated | 3.7M | $185.9M | 6.9% | Held |
| VANGUARD CAPITAL MANAGEMENT LLC | Diversified mechanical | 3.1M | $154.2M | 0.0% | — |
| Driehaus Capital Management LLC | Other | 2.8M | $140.8M | 1.0% | -3.2% |
| STATE STREET CORP | Index provider | 2.6M | $131.5M | 0.0% | +15.2% |
| Paradigm Biocapital Advisors LP ★2 | Fundamental concentrated | 2.0M | $98.7M | 2.0% | +33.4% |
| Commodore Capital LP ★3 | Fundamental concentrated | 1.9M | $96.5M | 5.6% | -19.9% |
| TCG Crossover Management, LLC ★3 | Fundamental concentrated | 1.9M | $95.9M | 2.7% | Held |
| TANG CAPITAL MANAGEMENT LLC ★2 | Fundamental diversified | 1.9M | $95.4M | 4.8% | Held |
| WELLINGTON MANAGEMENT GROUP LLP | Long only active | 1.8M | $92.0M | 0.0% | +17.8% |
| Capital International Investors | Long only active | 1.7M | $88.1M | 0.0% | -50.0% |
| GEODE CAPITAL MANAGEMENT, LLC | Index provider | 1.7M | $86.8M | 0.0% | +3.7% |
| JANUS HENDERSON GROUP PLC | Diversified mechanical | 1.7M | $83.6M | 0.0% | -9.5% |
| RA CAPITAL MANAGEMENT, L.P. ★2 | Fundamental diversified | 1.6M | $81.8M | 0.9% | Held |
| PRICE T ROWE ASSOCIATES INC /MD/ | Diversified mechanical | 1.6M | $80.6M | 0.0% | -0.2% |
| Remedium Capital Partners, LLC ★2 | Fundamental diversified | 1.5M | $73.5M | 26.1% | Held |
| Affinity Asset Advisors, LLC ★2 | Fundamental diversified | 1.3M | $64.5M | 3.8% | -10.7% |
| BANK OF AMERICA CORP /DE/ | Bank broker | 1.2M | $61.9M | 0.0% | +192.6% |
| BAKER BROS. ADVISORS LP ★2 | Fundamental diversified | 1.0M | $50.4M | 0.3% | Held |
| BRAIDWELL LP ★2 | Fundamental diversified | 932.8K | $47.1M | 1.8% | -42.9% |
| FRANKLIN RESOURCES INC | Long only active | 882.8K | $44.5M | 0.0% | -20.4% |
| JPMORGAN CHASE & CO | Bank broker | 979.3K | $44.5M | 0.0% | +1455.7% |
| Caligan Partners LP ★3 | Fundamental concentrated | 878.1K | $44.3M | 3.1% | New |
| Siren, L.L.C. ★2 | Fundamental diversified | 818.6K | $41.3M | 1.1% | Held |
| Polar Capital Holdings Plc | Other | 792.8K | $40.0M | 0.2% | +7.1% |
| UBS Group AG | Bank broker | 671.2K | $33.9M | 0.0% | -1.4% |
| Capital World Investors | Long only active | 666.6K | $33.6M | 0.0% | +233.0% |
| EMERALD ADVISERS, LLC | Other | 613.4K | $30.9M | 1.0% | -3.6% |
| Candriam S.C.A. | Other | 610.3K | $30.8M | 0.2% | +43.4% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | Diversified mechanical | 585.1K | $29.5M | 0.0% | — |
| NORTHERN TRUST CORP | Index provider | 578.9K | $29.2M | 0.0% | +3.2% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | Index provider | 562.7K | $28.4M | 0.0% | -2.1% |
| Pictet Asset Management Holding SA | Diversified mechanical | 491.6K | $24.8M | 0.0% | -46.2% |
| VANGUARD FIDUCIARY TRUST CO | Diversified mechanical | 464.7K | $23.4M | 0.0% | — |
| EMERALD MUTUAL FUND ADVISERS TRUST | Other | 408.1K | $20.6M | 1.0% | -1.0% |
| SAMLYN CAPITAL, LLC ★2 | Fundamental diversified | 396.7K | $20.0M | 0.3% | New |
| ADAR1 Capital Management, LLC | Other | 338.3K | $17.1M | 1.0% | +893.6% |
| STEMPOINT CAPITAL LP ★2 | Fundamental concentrated | 335.2K | $16.9M | 1.6% | +935.3% |
| Blackstone Inc. | Other | 292.8K | $14.8M | 0.1% | -41.5% |
| VICTORY CAPITAL MANAGEMENT INC | Diversified mechanical | 292.1K | $14.7M | 0.0% | +100.0% |
| GOLDMAN SACHS GROUP INC | Bank broker | 269.9K | $13.6M | 0.0% | -1.9% |
| Woodline Partners LP | Other | 265.9K | $13.4M | 0.1% | Held |
| MORGAN STANLEY | Bank broker | 246.7K | $12.4M | 0.0% | +35.0% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | Bank broker | 207.3K | $10.5M | 0.0% | +233.2% |
| BOOTHBAY FUND MANAGEMENT, LLC | Diversified mechanical | 193.0K | $9.7M | 0.2% | New |
| Bank of New York Mellon Corp | Diversified mechanical | 191.4K | $9.7M | 0.0% | -0.7% |
Exits are not a bearish signal: our backtest shows stocks specialists exit keep outperforming for 3+ quarters — selling usually means profit-taking, not a forecast.
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